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Drug and Alcohol Dependence In these adults, 22–70 years of age, older smokers showed the most volume loss. Subcortical white matter (WM), thalamus, cerebellar cortex, and corpus callosum were most affected. Higher cigarette pack-years related to smaller volumes in several subcortical regions. Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure have primarily employed voxel-based morphometry, and the most consistently reported finding was smaller volumes or lower density in anterior frontal regions and the insula. Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers. Non-smokers (n = 43) and smokers (n = 40), 22–70 years of age, completed a 4 T MRI study. Bilateral total subcortical lobar white matter (WM) and subcortical nuclei volumes were quantitated via FreeSurfer. In smokers, associations between smoking severity measures and subcortical volumes were examined. Smokers demonstrated greater age-related volume loss than non-smokers in the bilateral subcortical lobar WM, thalamus, and cerebellar cortex, as well as in the corpus callosum and subdivisions. In smokers, higher pack-years were associated with smaller volumes of the bilateral amygdala, nucleus accumbens, total corpus callosum and subcortical WM.

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6, 2016-- Philip Morris International Inc. (“PMI”) (NYSE / Euronext Paris: PM) on Dec. 5 submitted a Modified Risk Tobacco Product (MRTP) application for its electronically heated tobacco product with the U.S. Food and Drug Administration’s (FDA) Center for Tobacco Products. This is consistent with the company’s stated goal of submitting its MRTP application in 2016. PMI anticipates the FDA taking a minimum of 60 days to complete an administrative review to determine whether to accept the application for substantive review. Philip Morris International Inc. (PMI) is the world’s leading international tobacco company, with six of the world's top 15 international brands and products sold in more than 180 markets. In addition to the manufacture and sale of cigarettes, including Marlboro, the number one global cigarette brand, and other tobacco products, PMI is engaged in the development and commercialization of Reduced-Risk Products (“RRPs”).

Signs are posted on the sides of ash trays advising the campus community of the upcoming change. "I actually just heard right now, so yeah, I'm very surprised. Kind of shocked but hey, maybe it's good for all of us," said Cal Poly student Mateo Cuellar. The new policy is in response to a systemwide CSU Executive Order issued in April. Chancellor Timothy White directed that all 23 campuses be smoke and tobacco-free September 1st. Right now, there are 73 designated smoking areas at Cal Poly. Student Ellie Vutova says too many students smoke. She believes the new policy is a good idea. "Hopefully it will curb their bad habits but honestly, I'm sure they might just smoke anyway," said Vutova. We came across several smokers who did not want to be on camera but said they do not agree with the policy and think it should be their own choice whether they want to smoke. In a statement to KSBY, the university said, in part: "If compliance remains a challenge after an extensive education and outreach program, the university reserves the right to institute fines under Assembly Bill 795." Smoking, vaping, and the use of tobacco will also be prohibited in all personal vehicles on campus property, sidewalks and campus residences.

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